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Unravel the Science of Ongoing VOC Damage in Sickle Cell Disease

The driving mechanism that causes complications in patients with sickle cell disease (SCD) goes beyond red blood cells (RBCs).¹ Vaso-occlusive crises (VOCs) are the clinical hallmark of this disease and originate from ongoing, often silent vaso-occlusion.^2,3 Vaso-occlusion is largely driven by multicellular adhesion, which itself is a result of the chronic inflammatory state of the blood vessels of people with SCD.¹

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VOC, vaso-occlusive crisis.

Multicellular adhesion, a major driver of vaso-occlusion and VOCs

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to see how SCD progresses to a chronic inflammatory vascular disorder

Vaso-occlusion and vaso-occlusion crises lead to end-organ damage

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to see how end-organ damage is the result of ongoing vaso-occlusion and recurrent VOCs

References: 1. Conran N, Franco-Penteado CF, Costa FF. Newer aspects of the pathophysiology of sickle cell disease vaso-occlusion. Hemoglobin. 2009;33(1):1-16. 2. Puri L, Nottage KA, Hankins JS, Anghelescu DL. State of the art management of acute vaso-occlusive pain in sickle cell disease. Paediatr Drugs. 2018;20(1):29-42. 3. Ballas SK, Gupta K, Adams-Graves P. Sickle cell pain: a critical reappraisal. Blood. 2012;120(18):3647-3656.