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• SCD Pathophysiology

  Mechanism of disease

  Vaso-occlusion, haemolysis, and anaemia

• Vaso-Occlusion and VOCs

  Clinical hallmark of SCD

  The cycle of vaso-occlusion and VOCs

• Clinical Impact of VOCs

  Vaso-occlusion, VOCs, and end-organ damage

  VOCs and mortality

• Societal Impact of VOCs
  and SCD

  Increased hospitalisation and cost of care

  Cognitive and psychological effects

  Social, educational, and employment effects

• SCD Around the World

  Common genotypes

  One of the most common monogenic disorders